Both H&E staining of liver sections (Fig. 1J), and NAS (Fig. 1K), the quantitative result of H&E staining, showed HFD‐induced liver damage attenuated in MD2−/− HFD mice and HFD mice treated with L6H21 at 10 or 20 mg/kg. This evidence concerns the gene LY96 and digestive system neoplasm.