We have employed whole‐exome sequencing (WES) in combination with arrhythmia‐related gene‐filtering to explore the possible causative gene for this family, a novel nonsense heterozygous mutation (c.565C>T/p.Arg189*) of GPD1L was identified may underlie the inherited arrhythmia. The gene discussed is GPD1L; the disease is Arrhythmia.