Murine cytomegalovirus (MCMV) infection increases Fas expression and Fas-mediated apoptosis, leading to reduced number of hematopoietic progenitor cells and contributing to CMV-induced myelosuppression [125], whereas latent infection of myeloid progenitors by human CMV (HCMV) are refractory to Fas-mediated killing through the cellular IL-10/PEA-15 pathway, and HCMV infection in fibroblasts suppresses Fas expression and protects the cells against Fas-mediated apoptosis through de novo virus-encoded gene expression [126,127]. This evidence concerns the gene FAS and cytomegalovirus infection.