The E6 oncoprotein of HPV can inhibit TNF-mediated apoptosis through interacting with the death domain of the TNF-R1 and blocking TNF-R1 interaction with TRADD in mouse fibroblasts, human monocytes/histocytes, and osteosarcoma cells [88,89,90]. Here, TNFRSF1A is linked to osteosarcoma.