Some of these inflammatory mediators, such as IL-1β and TNF-α, bind to receptors on the plasma membrane of the cell, which results in the activation of intracellular signaling pathways that activate IKK-β and JNK-1, promoting the perpetuation of this inflammatory reaction, as implicated in conditions such as atherogenesis and insulin resistance [30,31]. This evidence concerns the gene IL1B and Insulin resistance.