ARID4B and myeloid sarcoma: BCAA, Phe, and Tyr have been proved to be predictive of DM2 [12, 13] and CVD [11] up to 12 years prior to disease manifestation, BCAA and Tyr were related with MS diagnosis within 4-year period [13], whereas BCAA and Phe were shown to be significantly positively correlated with IR values measured 18 months later [14].