In disease, copeptin has been found to be of prognostic value in diverse conditions such as sepsis (Seligman et al. 2008), septic and haemorrhagic shock (Morgenthaler et al. 2007), lower respiratory tract infections (Müller et al. 2007), cardio- and cerebrovascular disease (Sun et al. 2015; Stoiser et al. 2006; Marston et al. 2016; Greisenegger et al. 2015) and for end stage renal failure, coronary heart disease and all-cause mortality in patients with type 1 diabetes (Velho et al. 2016). The gene discussed is AVP; the disease is Sepsis.