These newly identified somatic mutations of DNA/chromatin modifiers and structural organizers are in agreement with previous karyotyping/FISH-based analyses of AML patients, which already identified recurrent chromosomal translocation or abnormality of genes encoding various members of epigenetic “writers” (MLL/KMT2A, NSD1/KMT3B, NSD3/WHSC1L1/KMT3F) (27–31), “erasers” (JARID1A/KDM5A) (32, 33), and “readers” (PHF23) (32, 34). Here, NSD3 is linked to acute myeloid leukemia.