Similar mechanisms might be also functional among DNMT3A-mutated leukemias (Figure 1D, right) where DNMT3A mutations perturb efficient CpG methylation at cis-regulatory sites leading to elevated histone acetylation and increased binding of DOT1L-associated complexes that harbor YEATS-containing AF9 and ENL (96). The gene discussed is MLLT3; the disease is leukemia.