The produced NUP98-JARID1A or NUP98-PHF23 oncoproteins were highly potent in inducing AML transformation in vitro/vivo and rely on their H3K4me3-“reading” PHD finger domain to maintain high expression of “stemness” nodes, notably HOX and MEIS1 (32, 118). This evidence concerns the gene NUP98 and acute myeloid leukemia.