As shown in Figure 2(a,b), compared to control rats, DRD1, DRD3‐5, and DAT mRNA and protein levels were upregulated in the PFC of MD rats, DRD1, DRD5, and DAT mRNA and protein levels were upregulated and DRD2 mRNA and protein levels were downregulated in the PFC of CUPS rats. This evidence concerns the gene DRD1 and Menkes disease.