The importance of tight metabolic control wasn’t unequivocally demonstrated until 1993 when the Diabetes Control and Complications Trial (DCCT) followed type 1 diabetic patients with mild or no retinopathy for a mean of 6.5 years, and found that intensive insulin therapy reduced the adjusted mean risk for development of retinopathy by as much as 76% [5]. Here, INS is linked to retinal disorder.