Table 1 shows the distribution of the immunoscore of CD68+ macrophages and CD138+ plasma cells in periapical cysts and granulomas. There was no statistical significant differences whe comparing clinical (age, gender, and presence of symptoms and sinus tract) and image (CBCT mean greater diameter) data with both CD68 and CD138 immunoscores (p>0.05) ( Table 2). Figures 2 and 3 show the distribution of CD68 + macrophages and CD138+ plasma cells and CBCT scans of a periapical cyst and a periapical granuloma. This evidence concerns the gene CD68 and periapical granuloma.