Table 1 shows the distribution of the immunoscore of CD68+ macrophages and CD138+ plasma cells in periapical cysts and granulomas. There was no statistical significant differences whe comparing clinical (age, gender, and presence of symptoms and sinus tract) and image (CBCT mean greater diameter) data with both CD68 and CD138 immunoscores (p>0.05) ( Table 2). Figures 2 and 3 show the distribution of CD68 + macrophages and CD138+ plasma cells and CBCT scans of a periapical cyst and a periapical granuloma. The gene discussed is SDC1; the disease is periapical granuloma.