As shown in Table 1, methylation of HOXD10 was more frequently in patients with vessel cancerous embolus (p < 0.05) and poorly differentiated tumors (P < 0.05), but no association was found between HOXD10 methylation and age, gender, HBV infection, cirrhosis, tumor size, number of lesions, TNM stage, and lymph node metastasis (all P > 0.05).The median follow-up period for patients was 23 months (range, 0–76 months).Four patients in the unmethylated group and 17 patients in the methylated group were lost to follow-up. This evidence concerns the gene HOXD10 and Cirrhosis.