CD4 and cervical cancer: In this regard, some valuable results of a flow cytometric study of cell suspensions prepared from tumor-draining lymph nodes of female patients with stage IB1 cervical cancer [11, 12] are worth mentioning: in this study, the authors found altered proportions of CD4+ and CD8+ Т cells, along with altered expression of T-cell activation and immune checkpoint markers, increased frequencies of CD4+ and CD8+ Tregs, as well as a decreased CD3+CD8+/Treg ratio.