Interestingly, in CIN/CC patient group, a strong association was seen between the frequencies of CD4+CD95+ T cells and CD4+CD25high cells (along with a more moderate correlation between CD4+CD95+ cells and CD4+FoxP3+ cells, Fig.10) suggesting that these cell populations may be involved in a common mechanism, whereas no such relationship was detected for CD8+CD95+ T cells. This evidence concerns the gene CD8A and cervical squamous intraepithelial neoplasia.