Taken together, women with early neoplastic lesions of the cervix, such as carcinoma in situ and microinvasive carcinoma, displayed a coordinated increase in expression of markers of regulatory T cells in blood CD4+/CD8+ lymphocytes, along with more pronounced cross-relationships between Treg numbers, CD95 expression on CD4+/CD8+ T cells, and apoptosis, with these interrelated changes being suggestive of the mechanisms responsible for the development of systemic immunological deficiency throughout cervical cancer progression. Here, CD4 is linked to in situ carcinoma.