Fewer data are available on whether these processes can spread to systemic level; nevertheless, importantly, most investigators point to the fact that the increase in the level of peripheral blood CD4 Tregs is an early event in cervical cancer development, occurring at the stage of CIN2–3 [15, 16, 30], and is probably linked with the persistence of high-risk HPV infection [14]. Here, CD4 is linked to cervical carcinoma.