CD8A and neoplasm: Given that in experimental settings CD8+ T cells were shown to convert to suppressor CD8 Tregs under the influence of the tumor cell microenvironment [35, 37], it can be assumed that expansion of CD8 Tregs observed in systemic circulation of cervical cancer patients at a pre-metastatic stage might reflect important local level changes in their quantities, that provide a foothold for further tumor dissemination.