Both HF-delay and LF-HF different transcriptomes were characterized by a higher proportion of genes related to digestion, and there were three common transcriptional regulators between the HF-delay and LF-HF different genes, namely recombination signal binding protein for immunoglobulin kappa J region-like (RBPJL), pancreas specific transcription factor 1a (PTF1A) and NR5A2. The gene discussed is NR5A2; the disease is hydrops fetalis.