STAT3 and neoplasm: HDAC inhibition influences the acetylation not only of histones (FoxP3 locus in Tregs, important for their maturation) [44], but also of major transcription factors such as nuclear factor kappa-light-chain-enhancer for activated B cells (NF-κB) or signal transducer and activator of transcription 3 (Stat3) [45, 46], major proinflammatory pathway factors affecting the proinflammatory cytokine secretion profile in immune cells [47] and decreasing the proliferation and apoptosis of tumour cells [48].