NLRP3 and infection: By examining separately the contributions of caspase-1 and caspase-11 to T. gondii infection control (using mouse knockout cells) we also show that the reduction in infection load caused by ATP treatment requires only caspase-1, and not caspase-11, supporting the hypothesis that a canonical NLRP3 is activated by the P2X7 receptor, to reduce T. gondii infection in macrophages.