SIRT6 and endothelial dysfunction: In terms of the important role of SIRT6 in regulating endothelial dysfunction and atherosclerosis (Liu et al., 2016; Xu et al., 2016a,c; Zhang et al., 2016), Icariin has recently been reported as a SIRT6 pharmacological activator in vitro and in vivo (Chen et al., 2015), pinpointing the potential contribution of SIRT6 activation to the atheroprotective effects of Icarrin.