MAOB and Parkinson disease: The anti-PD effect of zonisamide, however, may be related to the inhibition of dopamine metabolism via inhibition of monoamine oxidase-B (MAO-B), the stimulation of dopamine release from striatum, and the blockade of T-type calcium channels (Shahed and Jankovic, 2007; Sonsalla et al., 2010; Miwa et al., 2011).