Blockade of the KCa3.1 channel has also been shown to attenuate the Aβ-induced JNK MAPK pathway, resulting in downregulation of the inflammatory factors IL-1β, TNF-α, iNOS and COX-2 in the brain in a mouse model of Alzheimer’s disease (AD; Wei et al., 2016; Yi et al., 2016b). This evidence concerns the gene MAPK8 and Alzheimer disease.