In general, it has been well established that 14-3-3 proteins play key roles in cell cycle control, apoptosis and cancer progression in non-neuronal cells (van Hemert et al., 2001; Hermeking and Benzinger, 2006; Morrison, 2009; Freeman and Morrison, 2011; Gardino and Yaffe, 2011; Dar et al., 2014). Here, YWHAQ is linked to cancer.