We found the novel PCDH18 mutations including c.1474C>G (p.P492A), c.2337A>G (p.S780P), and c.2976G>T (p.N992K) missense mutations, and a c.2556_2557delTG frameshift mutation in HCC (Fig. 5a). The gene discussed is PCDH18; the disease is hepatocellular carcinoma.