TACC3 and breast carcinoma: An association between TACC family genes and cancer has been reported: over-amplification of TACC1 and TACC2 is observed in breast cancer, and the TACC3 locus is associated with multiple myeloma54; the three family members are characterized by a C-terminal domain (TACC domain)53 and are suggested to play distinct roles based on their distinct patterns of centrosome association55.