NEFL and Huntington disease: Compared to wild-type littermates (Fig. 1A and B), HD mice exhibited ~9–fold increase of NfL in serum (p < 0.0001; 121.3 ± 19.16, n = 12 and 13.79 ± 1.591, n = 10) and ~2.3 –fold increase of NfL in CSF (p = 0.0142; 491.1 ± 73.04, n = 12 and 215.9 ± 65.61, n = 9).