Furthermore, baseline anti-HBc levels can predict the hepatitis B e antigen (HBeAg) seroconversion rate, which can be used as a reliable predictor of the efficacy of peginterferon and nucleos(t)ide analogues therapy, and could be used for optimizing the antiviral therapy of chronic hepatitis B infection (CHB)12–14. Here, KRT88P is linked to chronic hepatitis B virus infection.