IL-17A-deficient mice with HFD developed obesity to the similar extent to that of HFD-fed wild-type (WT) mice (Supplementary Figure 3a), and the increase of dermal γδ T cells was observed in both WT and IL-17A-deficient mice (Supplementary Figure 3b,c). The gene discussed is IL17A; the disease is obesity due to melanocortin 4 receptor deficiency.