On day 14 after viral infection, RT-qPCR analysis showed that the expression levels of endogenous NANOG, OCT4, and SOX2 were increased in H9-OCT4pGFPdF populations co-expressing OSKM and circBIRC6 (OSKMB) or circCORO1C (OSKMC) compared with H9-OCT4pGFPdFs expressing only OSKM (Supplementary Fig. 5c). The gene discussed is SOX2; the disease is viral infectious disease.