This is in contrast to the expectations that HF-fed mice develop obesity and glucose intolerance (29) because TRPC1 KO mice fed a HF-diet and exercised were less insulin resistant than their WT counterparts, indicative of protection from type II diabetes risk, yet GLUT4 expression was unaltered in hind leg biceps femoris skeletal muscle or subcutaneous adipose tissue. This evidence concerns the gene SLC2A4 and obesity due to melanocortin 4 receptor deficiency.