SLC2A4 and Insulin resistance: Using a homeostatic model assessment of insulin resistance (HOMA IR), we found that, once more, TRPC1 KO mice fed a HF diet and exercised were less insulin resistant (p < 0.01) than WT mice fed a HF diet and exercised (Fig. 3D) although this difference was not because of altered expression of GLUT4 in the subcutaneous adipose tissue (Fig. 4A) or skeletal muscle (Fig. 4B).