However, when calculated as a -fold change, there was no change in body weight when comparing WT to TRPC1 KO mice (Fig. 2C), but body fat mass was significantly decreased (p < 0.05) in TRPC1 KO mice fed a HF diet and exercised compared with WT mice fed a HF diet and exercised (Fig. 2F). This evidence concerns the gene TRPC1 and hydrops fetalis.