TRPC1 and hydrops fetalis: In addition, TRPC1 KO mice fed a HF diet and subjected to sedentary cage activity had decreased (p < 0.05) adipocytes from 160–200 μm when compared with WT mice fed a HF diet and subjected to sedentary cage activity (Fig. 5), suggesting that loss of TRPC1 decreases the number of larger adipocytes, which could result in the decreased fat mass observed in Fig. 2.