Moreover, our study identified two AIPmut exclusively found in Brazilian patients and also shows, for the first time, LOH in the tumor DNA from an acromegaly patient harboring the A299V AIPmut. Although the study has included all types of pituitary adenomas matching the inclusion criteria, the acromegaly group is overrepresented, probably because we are a state referral center for the treatment of acromegaly, and the NFPA group has a limited number of patients; therefore, we cannot draw a definitive conclusion on the prevalence of AIP mutations in this type of adenoma. Here, AIP is linked to non-functioning pituitary adenoma.