In summary, our study has revealed novel roles of MSI-2-c-FOS axis during CC progression, and the restoration of tumor suppressors miR-143 and miR-107 by Mithramycin A via activation of p53 could be an effective approach for the downregulation of MSI-2, resulting in the inhibition of invasion and metastasis (Fig. 7). The gene discussed is FOS; the disease is neoplasm.