Numerous studies have reported that MSI-2 protein is frequently elevated in tumors, including brain, breast, pancreas, colon, lung, ovary and bladder cancer [16], and its overexpression were closely associated with aggressive characteristics and poor prognosis for patients with pancreatic cancer and chronic myeloid leukemia [38, 39]. Here, MSI2 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.