miR-34 family members are well-known TS-miRs which repress the expression of several targets involved in regulation of cell cycle and proliferation, like BCL-2, Notch1, cyclin E2, cyclin-dependent kinases 4 and 6 (CDK4 and CDK6), in MM [27] and other cancers [26]. Here, CDK4 is linked to Miyoshi myopathy.