Furthermore, through mouse and rat models, six genes in our network (ARID5B, CYB5R4, EGLN1, RETN, TLR5, and NRG3) have been previously associated with several CAC risk factors including diabetes, insulin resistance, LDL cholesterol, and triglycerides (all associations listed in Additional file 2: Supplementary Text). This evidence concerns the gene CYB5R4 and Insulin resistance.