Whereas enhanced AdipoR1/R2 expression on the myeloid cell lineage has for example been associated with anti-inflammatory (M2) macrophage polarization and suppression of foam cell formation [26,27], the decreased AdipoR1 expression on classical CD14++CD16- monocytes may be involved in their inflammatory fate and pivotal role in the development of cardiovascular disease [28,29]. The gene discussed is CD14; the disease is cardiovascular disorder.