Expression of Il6 –a factor promoting a tumor stimulating inflammation and metastasis in prostate cancer [35]–was also increased early (day 3 and 7) in MLL-LNs, as well as Itgam (day 3 and 7)–expressed on a diversity of myeloid cells (for example myeloid derived suppressor cells, known to be recruited to pre-metastatic niches) [36]. This evidence concerns the gene KMT2A and Familial prostate cancer.