KMT2A and prostate neoplasm: By using two different types of orthotopic rat prostate tumors–the locally aggressive AT1-tumor with poor metastatic ability and the locally aggressive MatLyLu (MLL)-tumor with high metastatic ability [18]–we compared the global gene expression profiles in tumor tissue, in the surrounding benign parts of the prostate (TINT) and in regional LNs [11].