As the presence of parietal cells in the progenitor zone, rather than the base of the glands, is necessary for the maintenance and development of the Muc6-secreting MNC [96], inhibition and depletion of parietal cells, as in other gastric pathologies (Menetrière’s disease and pernicious anaemia) [97–98], results in pit enlargement and expansion of the MNC population. The gene discussed is MUC6; the disease is pernicious anemia.