In a breast cancer case-control study with similar number of AA and EA women, we replicated several SNPs identified in previous GWAS of AM and ANM in the EA group, including the top GWAS signals rs7759938 in LIN28B and rs16991615 in MCM8. Nevertheless, the replication of the same set of SNPs in AA women was not as successful. This evidence concerns the gene MCM8 and breast cancer.