IQGAP2 and colon adenocarcinoma: TCGA-COADREAD analysis showed low IQGAP2 mRNA expression in colon adenocarcinoma (fold change = -2.04), colon mucinous adenocarcinoma (fold change = -1.18) and rectal adenocarcinoma (fold change = -1.90) but no change in rectal mucinous adenocarcinoma (Fig 5B).