However, TCGA database showed increased IQGAP3 mRNA expression in gastric intestinal adenocarcinoma (fold change = 3.25), diffuse gastric adenocarcinoma (fold change = 2.51) and gastric mixed adenocarcinoma (fold change of 2.43) (Fig 4C). This evidence concerns the gene IQGAP3 and diffuse gastric adenocarcinoma.