DNMT3B and cancer: Since aberrant DNA methyltransferases (Dnmts) activity has been reported in numerous cancers [33–35], we examined the expression of the 3 major Dnmts: Dnmt1, Dnmt3a and Dnmt3b which are known to be involved in DNA methylation maintenance (Dnmt1) or de novo methylation (Dnmt3a and Dnmt3b).