It indicated that the expression level of multiple DEGs associated with immune system, including interleukin 1 Alpha (IL1A), interleukin 8 (IL8), C-C motif chemokine ligand 8 (CCL8), C-X-C motif chemokine ligand 10 (CXCL10) and C-X-C motif chemokine ligand 11 (CXCL11), were obviously up-regulated after ORFV infection (Fig 3A). The gene discussed is IL1A; the disease is infection.