In models of Fas- or LPS/GalN-induced apoptosis, simple steatosis or after partial hepatectomy, deletion of Caspase-8 turned out to be hepatoprotective,9, 21, 26 while in strong inflammatory injury models such as Concanavalin A treatment, NEMO/IKKγ deletion or MCD diet, Caspase-8 deficiency was associated with induction of necroptosis.9, 27 In our present study, we have demonstrated that feeding a Lieber-DeCarli diet is not related to a major inflammatory response. Here, CASP8 is linked to steatosis.