CASP8 and steatosis: However, it supports our previous study showing reduced steatosis, hepatic lipid storage and accumulation of FFAs in Casp8Δhepa mice fed with a steatohepatitis-inducing methionine-choline-deficient diet.21 We then reasoned that Caspase-8 is not only involved in apoptosis signaling, but also in the regulation of hepatic fat metabolism.