Ang II has a crucial role in the pathogenesis of hypertension and related end-organ damage29, 30 and is involved in the pathogenesis of renal disease.31 Ang II-induced hypertension is a commonly used animal model of hypertension.32, 33, 34 It has been found that Ang II induces hypertensive renal inflammation in rat RTE cells.6 Thus Ang II-induced inflammation model in HK-2 cells was used to examine the effects of BCL6 in vitro. The gene discussed is AGT; the disease is kidney disorder.