Renal inflammation has an important role in the development of hypertension.8, 9, 10 BCL6 gene encodes a protein containing six C-terminal zinc-finger motifs and an N-terminal POZ domain, and the BCL6 protein acts as a sequence-specific transcriptional repressor.26 BCL6 negatively regulates NF-κB expression and thereby inhibits NF-κB-mediated inflammation.17 NLRP3 inflammasome activation is involved in several inflammatory diseases.27, 28 However, it is unknown whether BCL6 would contribute to the NLRP3-mediated inflammation. This evidence concerns the gene NFKB1 and Hypertension.