Non-transformed cells treated with either iASPP-specific siRNA or shRNA reduced levels of apoptosis,8, 15 whereas silencing of iASPP in several cancer cell lines promoted apoptosis.12, 13, 16, 17, 18, 19, 20 Therefore, unlike keratinocytes, knockdown of iASPP did not induce but rather prevented autophagy in cancer cells. Here, PPP1R13L is linked to cancer.