In gastric cancer cells, TGF-β1-induced cell migration and invasion and reciprocal downregulation of E-cad could be abrogated by CRT knockdown.7 In MDCK cells, CRT regulates the EMT-like change of cellular phenotype by modulating the Slug/E-cad pathway through altered Ca2+ homeostasis.28 Our study supplies a new sight to investigate the close interaction of CRT with EGF-induced EMT in PC, which has not been reported to our knowledge. The gene discussed is EGF; the disease is gastric cancer.