The clinical significant of c-Myc, pERK, E-cad and Vimentin expression in PC are well studied in other and our previous study.29, 30, 31, 32 In the current study, CRT and Fibronectin overexpression had positive association with tumor differentiation, UICC stage and lymph nodes metastasis, respectively, while positive Integrinβ1 expression was closely associated with UICC stage of PC patients (Table 2). The gene discussed is CALR; the disease is pachyonychia congenita.