In 68 cases of PC tissues, proteins were overexpressed in 63.2% (43/68) of CRT, 50% (34/68) of Fibronectin, 69.1% (47/68) of Integrinβ1, 52.9% (36/68) of c-Myc, 60.2% (41/68) of pERK, 38.2% (26/68) of E-cad and 30.8% (21/68) of Vimentin in IHC assays, respectively (Table 1). The gene discussed is EIF2AK3; the disease is pachyonychia congenita.