In addition, CRT might regulate the above signaling via mediating Ca2+ homeostasis just as the research in MDCK cells.28 Increasing evidences have demonstrated that intracellular alteration of Ca2+ homeostasis in various cancer cells is closely involved in tumor initiation, angiogenesis, progression and metastasis.50 In the current study, the increase of both intracellular Ca2+ and Integrinβ1, Fibronectin and c-Myc expression induced by EGF and ionomycin is finally regulated by CRT. The gene discussed is CALR; the disease is cancer.