It is well known that EMT (the initial transformation from benign to invasive carcinoma following E-cad decrease) and mesenchymal–epithelial transition (MET, the reverse of EMT in the later metastatic stage with the rescue of E-cad) are recognized as critical events for cancer metastasis.33, 34 Overexpression of CRT rescued the change of EMT-related proteins (E-cad, ZO-1, β-catenin and Fibronectin) induced by EGF in CRT-silencing PC cells, which further indicates that CRT also has a significant role in EGF-induced MET in PC. The gene discussed is CALR; the disease is pachyonychia congenita.