Activation of Wnt/β-catenin pathway has been associated with metastasis and proliferation.35, 36 Differential β-catenin expression levels and localisation are associated with cancer prognosis.37 We observed that: (1) miR-99a expression inversely correlated with β-catenin expression and (2) E2F2 and EMR2 expression correlated with β-catenin expression in the lung cancer biopsies. The gene discussed is ADGRE2; the disease is lung cancer.