However, the specific function of E2F2 is contradictory.19, 20, 21, 22, 23, 24 EMR2, a member of the EGF-TM7 receptor family, is a cell surface receptor involved in cell migration and trafficking.25, 26 Interestingly, a significant but low number of colorectal carcinomas are positive for EMR2 and EMR2 is relevant in breast cancer progression.27, 28 In NSCLC cells, we found that the action of both E2F2 and EMR2 concurred to the suppressor function of miR-99a, thereby supporting a proliferative and pro-oncogenic role for these proteins. The gene discussed is ADGRE2; the disease is non-small cell lung carcinoma.