Among the most downregulated microRNAs, we focussed on miR-99a that has been reported to be deregulated in NSCLC and renal cell carcinoma.9, 10 miR-99a has been associated with the cancer stem cell (CSC) population in a model of breast cancer but its role in lung CSCs remained unknown.11 Here, we describe two novel targets of miR-99a, E2F2 (E2F transcription factor 2) and EMR2 (EGF-like module-containing, mucin-like, hormone receptor-like 2), and their association with epithelial-to-mesenchymal transition (EMT) repression and expression of stem cell genes. This evidence concerns the gene E2F2 and hereditary clear cell renal cell carcinoma.