The studies of E2F2 with EMT, previously associated with metastases and chemoresistance,30, 31 are contradictory.20, 32, 33 In the current study, we found that all mice tumours formed by miR-99a overexpression showed a fusocellular pattern different from the tumours formed in the control group, supporting a role of miR-99a in EMT inhibition concomitant to a downregulation of stem cell genes. Here, E2F2 is linked to neoplasm.