In contrast, rats overexpressing HNF4α have a reduced liver tumor development.22, 41 By inhibition of the transcription of epithelial-to-mesenchymal transition-regulatory genes such as Snail and Slug, HNF4α prevents migration and invasion in HCC.43, 44 Therefore, we propose a novel link between HNF4α and PED expression in HCC. This evidence concerns the gene SNAI1 and hepatocellular carcinoma.