FOXO3 and neoplasm: In our study, the data showed that RNAi directed against FOXO3 significantly increased the growth rate of tumor cells in a time-dependent manner, and the highest proliferation rates were 28.02±2.85 and 35.36±2.67% for siFOXO3-1 and siFOXO3-2, respectively, on day 8 (P<0.01, Figure 3a).