To investigate the FOXO3 expression in pancreatic cancer, western blotting was performed on a human immortalized pancreatic ductal epithelial cell line HPDE6 and a panel of four pancreatic cancer cell lines (ASPC1, Bxpc-3, Capan-2, and PANC1) Our data showed that the expression of FOXO3 protein was strongly positive in human immortalized pancreatic ductal epithelial cell compared with that in pancreatic cancer cell lines (Figure 1a). This evidence concerns the gene FOXO3 and familial pancreatic carcinoma.