Intriguingly in this study, we found that miR-106a-5p could not be able to exert significant effects on cell proliferation though its target PAK5 was reported to be involved in regulation of tumor cell proliferation.38, 39 It suggested complicated redundancies might exist downstream of miR-106a-5p but upstream of PAK5 which possessed a mystical power to recover potential regulation on RCC cell proliferation by PAK5. The gene discussed is PAK5; the disease is renal cell carcinoma.