GBP2 and breast cancer: This data supports the finding that high GBP2 levels are associated with improved metastasis-free survival in node-negative breast carcinomas.12 It should be noted that increasing IFN-γ concentration failed to further increase GBP2 expression in cells (Supplementary Figure 7b) but increased expression of other proteins that promote breast cancer metastasis.40 This may provide an additional explanation for why IFN-γ is not an efficient breast cancer therapy.