TGFB1 and systemic lupus erythematosus: It is now well accepted that BMP-7, a key member in the TGF-β superfamily, plays an important role in kidney diseases.27 Zeisberg’s group28 reported treatment with rhBMP-7 led to improved renal function, histology and survival in mice deficient in the alpha3-chain of type IV collagen and MRL/MpJlpr/lpr lupus mice.