SIRT3 and cancer: 8-Oxoguanine DNA glycosylase (OGG1) is a DNA repair enzyme serving as a deacetylation substrate of SIRT3 in cancer cells.28 Western blot analysis showed SIRT3 overexpression increased total OGG1 protein and decreased its acetylation level in oxidative injured hepatocytes (Figure 4h and Supplementary Figure S3b).