Aligned collagen organization is regarded as the 'highway' for the migration of multiple types of cancer cells, which is mainly modified by PLOD2 via building a foundation of collagen molecular crosslinks.29 Several studies have demonstrated that PLOD2 is modulated by various factors, such as HIF-1-α, TGF-β and microRNA-26a/b under distinct contexts.15, 19, 20 Although the biological role of PLOD2 has been studied in mouse lung cancer model,13 whether PLOD2 is involved in human lung cancer progression is still unclear. This evidence concerns the gene PLOD2 and lung cancer.