Furthermore, the picrosirius red staining and Masson’s trichrome of tumors showed that the decrease in metastasis was possibly due to PLOD2-induced collagen deposition and fibrillar organization (Figures 3j–k), consistent with the previous report.10 Collectively, our results inferred that EGFR inhibitors attenuated NSCLC metastasis, at least in part through hampering the expression of PLOD2. This evidence concerns the gene PLOD2 and non-small cell lung carcinoma.