PLOD2 is a significant collagen synthetase that can induce collagen reorganization, providing a stabilized 'highway' for cancer cell migration.10 Therefore, collagen deposition and fibril organization were detected by picrosirius red staining, which showed that collagen deposition was increased and the degree of fibrillar organization was enhanced in human lung adenocarcinoma tissues (Figures 1i and j). This evidence concerns the gene PLOD2 and lung adenocarcinoma.