However, the mechanisms of PLOD2 in direct migration capability needs to be further explored, in consideration of the migration capability is concerned with Rho proteins such as actin, myosin and so on.47 Moreover, because of the significant role of collagen in metastasis, some clinical antifibrosis drugs, such as pirfenidone and silibinin, may have novel therapeutic effects for malignant tumor patients. The gene discussed is PLOD2; the disease is cancer.