PLOD2 and neoplasm: Furthermore, the relationship between collagen organization and the ratio between HP/LP crosslinks (HP: hydroxylysyl-pyridinoline and LP: lysyl-pyridinoline) regulated by PLOD2 was confirmed via HPLC,45 stiffness measurements,13 ultrastructural analysis,45 picrosirius red staining10 and Masson’s trichrome staining.10, 45 Therefore, the change in collagen organization detected by staining in tumor tissues may suggest the possibility of metastasis via the 'highway'.