However, antiangiogenesis may lead to severe glucose and oxygen deprivation as well as GRP78 expression, which are HIF independent and closely related to apoptosis resistance.10 It is well known that GRP78 promotes tumour proliferation, survival, and metastasis.11 GRP78 overexpression confers resistance to a wide variety of chemotherapeutic agents in multiple tumour types, such as lung, bladder, stomach, breast, gastric, and epidermoid carcinoma. This evidence concerns the gene HSPA5 and squamous cell carcinoma.